Andrew Grace

Biography

Andrew Grace is Professor of Experimental Cardiology at the University of Cambridge. He trained in cardiology in London and Cambridge and then delivered a consistently high-volume interventional practice focused on arrhythmias over >30 years. He completed post-doctoral studies as a Fulbright Scholar in the Department of Medicine, University of California, San Diego returning to Cambridge as British Heart Foundation Senior Research Fellow. He is a recognized innovator having a particular interest in ‘disruptive’ technologies that have included devices, diagnostics and drugs. Some of his work has changed practice significantly and he made some of the ‘most important contributions’ to the development and implementation of subcutaneous defibrillators. His clinical research focus is currently on both activation mapping and risk prediction of ventricular fibrillation. He has spent over 25 years addressing the impact of genetic variation on the heartbeat and most recently has established a network of colleagues based respectively in Cambridge, Seattle, Sydney and San Diego to provide a physically robust model of cardiac electrical measurement extending from charge movements through structurally resolved sodium channels to surface recordings. Working with the Theory of Condensed Matter Physics Group (Cavendish Laboratory, Cambridge) and the Wellcome Trust Sanger Institute high-resolution charge density mapping of cardiac activation is being linked to multi-omics in single cells acquired through novel in vivo freeze-sampling; there is high anticipation of therapeutic target identification and rescue.